1. Saponin Nanoparticle Adjuvants Incorporating Toll-Like Receptor Agonists Drive Distinct Immune Signatures and Potent Vaccine Responses
Authors: Ou, B.S., Baillet, J., Filsinger Interrante, M.V., King, N.P., Appel, E.A.
Journal: Science Advances, 2024, 10(32), eadn7187
Abstract: This article explores the use of saponin nanoparticle adjuvants in vaccines, which incorporate Toll-like receptor agonists to drive unique immune responses, enhancing vaccine efficacy.
2. Biomimetic Non-ergodic Aging by Dynamic-to-covalent Transitions in Physical Hydrogels
Authors: Sen, S., Dong, C., D’Aquino, A.I., Yu, A.C., Appel, E.A.
Journal: ACS Applied Materials and Interfaces, 2024, 16(25), 32599–32610
Abstract: The research discusses the development of biomimetic hydrogels that exhibit non-ergodic aging through transitions from dynamic to covalent bonding, which can be used for various biomedical applications.
3. Label-Free Composition Analysis of Supramolecular Polymer-Nanoparticle Hydrogels by Reversed-Phase Liquid Chromatography Coupled with a Charged Aerosol Detector
Authors: Tang, S., Pederson, Z., Meany, E.L., Pellett, J.D., Appel, E.A.
Journal: Analytical Chemistry, 2024, 96(15), 5860–5868
Abstract: This study introduces a label-free method for analyzing the composition of supramolecular polymer-nanoparticle hydrogels, using advanced chromatography techniques.
4. Nanoparticle-Conjugated Toll-Like Receptor 9 Agonists Improve the Potency, Durability, and Breadth of COVID-19 Vaccines
Authors: Ou, B.S., Baillet, J., Picece, V.C.T.M., Lopez Hernandez, H., Appel, E.A.
Journal: ACS Nano, 2024, 18(4), 3214–3233
Abstract: This article highlights the development of nanoparticle-conjugated TLR9 agonists to enhance the effectiveness of COVID-19 vaccines, focusing on improved immune responses.
5. Sticky Gels Designed for Tissue-Healing Therapies and Diagnostics
Authors: Bailey, S.J., Appel, E.A.
Journal: Nature, 2024, 625(7995), 455–457
Abstract: This research presents sticky hydrogels engineered for use in tissue-healing therapies and diagnostics, offering a new approach to medical treatments and assessments.
Dr. Eric Andrew Appel is an exemplary researcher whose interdisciplinary expertise, innovative contributions, and leadership make him a strong contender for the Best Researcher Award. His ability to translate fundamental research into practical applications that address critical societal challenges is particularly noteworthy. While there are opportunities to enhance his global impact and public engagement, his current achievements and potential for future contributions position him as a deserving candidate for this prestigious award.