Eric Appel | Wildfire Prevention | Best Researcher Award


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Assoc Dr.Β  Stanford University, United States

Dr. Eric Andrew Appel is an accomplished chemist and materials scientist with a Ph.D. in Chemistry from the University of Cambridge, where his research focused on supramolecular hydrogels for drug delivery. Currently an Associate Professor and Director of Graduate Studies at Stanford University, Dr. Appel leads the Appel Lab, an interdisciplinary team focused on developing bioinspired soft materials for healthcare applications. He has co-founded multiple startups to commercialize his lab’s innovations, including injectable hydrogel technology for sustained drug delivery and wildfire prevention technology. Dr. Appel has received numerous prestigious awards and honors for his contributions to biomaterials science and engineering.

 

Professional Profiles:

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πŸŽ“ Education and Training

PhD, ChemistryUniversity of Cambridge (Jan 2013)
πŸ“œ Thesis: Cucurbit[8]uril-based Supramolecular Hydrogels: From Fundamentals to Applications in Drug DeliveryBS, Chemistry + MS, Polymers and Coating Science; Minor, Spanish – California Polytechnic State University, San Luis Obispo (June 2008)
πŸ“œ MS Thesis: Discrete Biodegradable Polymer Architectures by Macromolecular Self-Assembly
πŸ“œ BS Thesis: Chemical Changes of Hydrocarbons during Natural Attenuation in Large-Scale Mesocosms

πŸ”¬ Research Interests

🌱 The Appel Lab is an interdisciplinary team of scientists and engineers focused on creating bioinspired soft materials to address critical healthcare challenges. By integrating concepts from supramolecular chemistry, polymer science, and biology, we develop biomaterials that harness the dynamic and responsive properties of natural systems. Our mission is to utilize these technological advancements to deepen our understanding of fundamental biological processes and to engineer advanced healthcare solutions, aiming to reduce health disparities globally.

πŸ‘¨β€πŸ’Ό Professional Experience

Associate Professor and Director of Graduate StudiesDepartment of Materials Science & Engineering, Stanford University (Mar 2016 – present)Co-Founder and Chief Technical AdvisorAppel Sauce Studios (Nov 2022 – present)
πŸ§ͺ Appel Sauce Studios was established to commercialize an injectable hydrogel depot technology developed in the Appel lab at Stanford University, focusing on sustained biopharmaceutical delivery for vaccines and long-acting therapeutics across various therapeutic areas.Co-Founder and Chief Technical AdvisorSurf Bio (Jan 2021 – present)
🌊 Surf Bio was created to commercialize a copolymer excipient technology developed in the Appel lab at Stanford University, enhancing biopharmaceutical stability for next-generation protein therapeutics.Co-Founder, Executive Chairman, and Chief Technical AdvisorLaderaTECH (Oct 2018 – May 2020)
πŸ”₯ LaderaTECH focused on wildfire prevention technology and was awarded the Department of Energy’s NREL Best Venture Prize in 2020. The company was acquired by Perimeter Solutions in May 2020.Postdoctoral ResearcherDavid H. Koch Institute for Integrative Cancer Research, MIT (Feb 2013 – Feb 2016)
🧠 Advisor: Prof. Robert S. LangerPhD ResearcherMelville Laboratory for Polymer Synthesis, University of Cambridge (Oct 2008 – Jan 2013)
πŸ§‘β€πŸ”¬ Advisor: Prof. Oren A. SchermanResearcherAdvanced Organic Materials Division, IBM Almaden Research Center (Aug 2007 – Sept 2008)
πŸ§ͺ Advisors: Dr. Robert D. Miller and Dr. James L. Hedrick

πŸ† Selected Honors, Awards, and Scholarships

πŸ… Fellow, American Institute for Medical & Biological Engineering (2024)πŸ† Biomaterials Science Lectureship Award (2023)πŸ… Society for Biomaterials Young Investigator Award (2023)πŸŽ‰ Finalist, Falling Walls Breakthrough of the Year – Engineering & Technology (2023)πŸ… IUPAC Hanwha-TotalEnergies Young Polymer Scientist Award (2022)πŸ† ACS PMSE Young Investigator Symposium (Fall 2019)πŸŽ“ Delegate to the 53rd International Achievement Summit, Academy of Achievement (2019)πŸ† American Cancer Society Research Scholar Award (2019 – 2022)πŸ… American Diabetes Association Junior Faculty Development Award (2018 – 2021)πŸ† Hellman Faculty Scholarship (2016 – 2017)πŸ… PhRMA Research Starter Award (2016 – 2017)πŸŽ“ Frederick E. Terman Faculty Fellowship (2016 – 2018)πŸ† Wellcome Trust-MIT Postdoctoral Fellowship (2013 – 2017)πŸŽ“ Margaret A. Cunningham Immune Mechanisms in Cancer Research Fellowship Award (2015 – 2016)πŸ… NIH National Research Service Award from the NIBIB (awarded and declined) (2013 – 2016)πŸ† Jon Weaver PhD Prize, Royal Society of Chemistry (Macro Group UK) (2013)πŸ… Graduate Student Award, Materials Research Society (USA) (2012)πŸŽ“ Schlumberger PhD Studentship (2008 – 2012)πŸ… Doctoral Research Grant, Jesus College, Cambridge (2008 – 2012)πŸ… Finalist, California State University Research Competition (2008)

Assessment for Best Researcher Award

Strengths:

  1. Interdisciplinary Expertise:
    Dr. Eric Andrew Appel’s research spans across multiple disciplines, including supramolecular chemistry, polymer science, and bioengineering. His work in developing bioinspired soft materials for healthcare applications demonstrates a deep understanding of the intersection between these fields, making him a strong candidate for the Best Researcher Award.
  2. Innovative Contributions:
    Dr. Appel has co-founded several companies, such as Appel Sauce Studios, Surf Bio, and LaderaTECH, which aim to commercialize innovative technologies developed in his lab. His work on injectable hydrogel depot technology and wildfire prevention solutions showcases his ability to translate cutting-edge research into practical, impactful applications.
  3. Recognition and Awards:
    Dr. Appel has received numerous prestigious awards and fellowships, including the American Institute for Medical & Biological Engineering Fellowship, Biomaterials Science Lectureship Award, and the IUPAC Hanwha-TotalEnergies Young Polymer Scientist Award. These accolades highlight his outstanding contributions to the scientific community.
  4. Leadership and Mentorship:
    As an Associate Professor and Director of Graduate Studies at Stanford University, Dr. Appel has demonstrated strong leadership and a commitment to mentoring the next generation of scientists and engineers. His role in guiding and inspiring young researchers adds significant value to his candidacy.

Areas for Improvement:

  1. Broader Collaborative Impact:
    While Dr. Appel has a remarkable track record in founding companies and advancing specific technologies, there could be more emphasis on broader collaborative efforts across different scientific domains. Expanding his collaborative network might enhance his influence on a wider range of research areas.
  2. Public Engagement:
    Although Dr. Appel’s work is highly respected within the academic and scientific communities, increasing his involvement in public science communication could amplify the societal impact of his research. Engaging with a broader audience through public lectures, social media, or popular science publications could further elevate his profile.
  3. Global Research Initiatives:
    Dr. Appel’s research has significant implications for global health and environmental challenges. However, there is an opportunity to engage more directly with international research initiatives and collaborations that address these issues on a global scale, potentially increasing the reach and impact of his work.

 

✍️Publications Top Note :

1. Saponin Nanoparticle Adjuvants Incorporating Toll-Like Receptor Agonists Drive Distinct Immune Signatures and Potent Vaccine Responses

Authors: Ou, B.S., Baillet, J., Filsinger Interrante, M.V., King, N.P., Appel, E.A.

Journal: Science Advances, 2024, 10(32), eadn7187

Abstract: This article explores the use of saponin nanoparticle adjuvants in vaccines, which incorporate Toll-like receptor agonists to drive unique immune responses, enhancing vaccine efficacy.

2. Biomimetic Non-ergodic Aging by Dynamic-to-covalent Transitions in Physical Hydrogels

Authors: Sen, S., Dong, C., D’Aquino, A.I., Yu, A.C., Appel, E.A.

Journal: ACS Applied Materials and Interfaces, 2024, 16(25), 32599–32610

Abstract: The research discusses the development of biomimetic hydrogels that exhibit non-ergodic aging through transitions from dynamic to covalent bonding, which can be used for various biomedical applications.

3. Label-Free Composition Analysis of Supramolecular Polymer-Nanoparticle Hydrogels by Reversed-Phase Liquid Chromatography Coupled with a Charged Aerosol Detector

Authors: Tang, S., Pederson, Z., Meany, E.L., Pellett, J.D., Appel, E.A.

Journal: Analytical Chemistry, 2024, 96(15), 5860–5868

Abstract: This study introduces a label-free method for analyzing the composition of supramolecular polymer-nanoparticle hydrogels, using advanced chromatography techniques.

4. Nanoparticle-Conjugated Toll-Like Receptor 9 Agonists Improve the Potency, Durability, and Breadth of COVID-19 Vaccines

Authors: Ou, B.S., Baillet, J., Picece, V.C.T.M., Lopez Hernandez, H., Appel, E.A.

Journal: ACS Nano, 2024, 18(4), 3214–3233

Abstract: This article highlights the development of nanoparticle-conjugated TLR9 agonists to enhance the effectiveness of COVID-19 vaccines, focusing on improved immune responses.

5. Sticky Gels Designed for Tissue-Healing Therapies and Diagnostics

Authors: Bailey, S.J., Appel, E.A.

Journal: Nature, 2024, 625(7995), 455–457

Abstract: This research presents sticky hydrogels engineered for use in tissue-healing therapies and diagnostics, offering a new approach to medical treatments and assessments.

Conclusion:

Dr. Eric Andrew Appel is an exemplary researcher whose interdisciplinary expertise, innovative contributions, and leadership make him a strong contender for the Best Researcher Award. His ability to translate fundamental research into practical applications that address critical societal challenges is particularly noteworthy. While there are opportunities to enhance his global impact and public engagement, his current achievements and potential for future contributions position him as a deserving candidate for this prestigious award.

Prof Dr. Ang Cao | theoretical catalysis | Best Researcher Award


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Prof Dr. Ang Cao | theoretical catalysis | Best Researcher Award

Prof Dr. Ang Cao, zhejiang university, china

Prof Dr. Ang Cao is academic and researcher in the field of renewable energy, holds a PhD in Bio systems Engineering from Kangwon National University, South Korea. His academic journey has been marked by a profound dedication to advancing solar energy technologies, specifically in solar thermal harvesting and its integration into agricultural and architectural applications.

 

Professional Profiles:

Google scholar

Education Background πŸŽ“

Ph.D. in Chemical Engineering
09/2016 – 03/2018
Stanford University
Supervisor: Prof. Jens K. NΓΈrskov

Industrial Catalysis
09/2012 – 07/2018
Tianjin University

Work Experiences πŸ§ͺ

Researcher/Professor
03/2024 – Present
Zhejiang UniversityTenure-Track Researcher
07/2023 – 02/2024
Technical University of DenmarkPostdoctoral Researcher
03/2019 – 06/2023
Technical University of Denmark
Supervisor: Prof. Jens K. NΓΈrskovAssistant Researcher
07/2018 – 02/2019
Westlake University
Supervisor: Prof. Jianping Xiao

Highlights

Research interests in the theoretical description of surface, catalysts, and nanostructure.πŸ” Focus on reaction mechanism understanding and catalyst design of CO/CO2/N2 reduction.Β Rich experience in preparing catalysts derived from layered double hydroxides (LDHs) and perovskite.πŸ’» Proficient in DFT calculation, Machine Learning, and Spin Catalysis.

Skills πŸ’»

Material Analysis Techniques: XRD, SEM, TEM, XPS, TPR, TPD, Raman, BET, FT-IR, TGA, Gas chromatography, etc.Software: Quantum Espresso, Gaussian, VASP, MS Office, Origin, AutoCAD, Photoshop, etc.Programming Language: Python

πŸ“–Β Publications Top Note :

Synergy Effects on Sn-Cu Alloy Catalyst for Efficient CO2 Electroreduction to Formate with High Mass Activity

K Ye†, A Cao†, J Shao†, G Wang, R Si, N Ta, J Xiao, G Wang
Science Bulletin 65 (9), 711-719 163 2020

Monitoring Oxygen Production on Mass-Selected Iridium–Tantalum Oxide Electrocatalysts

YR Zheng, J Vernieres, Z Wang, K Zhang, D Hochfilzer, K Krempl, …
Nature Energy 7 (1), 55-64 128 2022

Elucidation of the Synergistic Effect of Dopants and Vacancies on Promoted Selectivity for CO2 Electroreduction to Formate

Z Li†, A Cao†, Q Zheng, Y Fu, T Wang, KT Arul, JL Chen, B Yang, NM Adli, …
Advanced Materials 33 (2), 2005113 116 2021

Relations between Surface Oxygen Vacancies and Activity of Methanol Formation from CO2 Hydrogenation Over In2O3 Surfaces

A Cao, Z Wang, H Li, JK NΓΈrskov
ACS Catalysis 11 (3), 1780-1786 105 2021

Understanding Oxygen Vacancies in Disorder-Engineered Surface and Subsurface of CaTiO3 Nanosheets on Photocatalytic Hydrogen Evolution

J Cai, A Cao, J Huang, W Jin, J Zhang, Z Jiang, X Li
Applied Catalysis B: Environmental 267, 118378 105 2020

Selectivity of Synthesis Gas Conversion to C2+ Oxygenates on fcc(111) Transition-Metal Surfaces

J Schumann, AJ Medford, JS Yoo, ZJ Zhao, P Bothra, A Cao, F Studt, …
ACS Catalysis 8 (4), 3447-3453 86 2018

Copper/Alkaline Earth Metal Oxide Interfaces for Electrochemical CO2-to-Alcohol Conversion by Selective Hydrogenation

A Xu, SF Hung, A Cao†, Z Wang, N Karmodak, JE Huang, Y Yan, …
Nature Catalysis, 1-8 76 2022

Electrocatalytic Nitrate-to-Ammonia Conversion with ~100% Faradaic Efficiency via Single-Atom Alloying

J Cai†, Y Wei†, A Cao†, J Huang, Z Jiang, S Lu, SQ Zang
Applied Catalysis B: Environmental 316, 121683 76 2022

Mechanistic Insights into the Synthesis of Higher Alcohols from Syngas on CuCo Alloys

A Cao, J Schumann, T Wang, L Zhang, J Xiao, P Bothra, Y Liu, …
ACS Catalysis 8 (11), 10148-10155 74 2018

The Deactivation of Cu–Co Alloy Nanoparticles Supported on ZrO2 for Higher Alcohols Synthesis from Syngas

GL Liu, T Niu, A Cao, YX Geng, Y Zhang, Y Liu
Fuel 176, 1-10 66 2016

Nanoparticles of Cu–Co Alloy Derived from Layered Double Hydroxides and Their Catalytic Performance for Higher Alcohol Synthesis from Syngas

A Cao, G Liu, Y Yue, L Zhang, Y Liu
RSC Advances 5 (72), 58804-58812 64 2015

Growing Layered Double Hydroxides on CNTs and Their Catalytic Performance for Higher Alcohol Synthesis from Syngas

A Cao, G Liu, L Wang, J Liu, Y Yue, L Zhang, Y Liu
Journal of Materials Science 51, 5216-5231 62 2016

A Spin Promotion Effect in Catalytic Ammonia Synthesis

A Cao, VJ Bukas, V Shadravan, Z Wang, H Li, J Kibsgaard, I Chorkendorff, …
Nature Communications 13 (1), 2382 60 2022

Metal-Organic Frameworks Derived Anatase/Rutile Heterostructures with Enhanced Reaction Kinetics for Lithium and Sodium Storage

G Liu, L Xu, Y Li, D Guo, N Wu, C Yuan, A Qin, A Cao, X Liu
Chemical Engineering Journal 430, 132689 55 2022

Origins of the Instability of Nonprecious Hydrogen Evolution Reaction Catalysts at Open-Circuit Potential

Z Wang, YR Zheng, J Montoya, D Hochfilzer, A Cao, J Kibsgaard, …
ACS Energy Letters 6 (6), 2268-2274 55