Assoc Prof Dr Denian Wang | Tumor microenvironment | Young Scientist Award

Assoc Prof Dr Denian Wang , West China Hospital of Sichuan University , China

Denian Wang is an Associate Professor at the Precision Medicine Center, West China Hospital, Sichuan University. His research focuses on tumor biology and cancer diagnostics, with a significant emphasis on the tumor microenvironment and early detection of lung cancer. Wang has garnered extensive funding for his work, including from the National Natural Science Foundation of China and the Natural Science Foundation of Sichuan Province. His research has resulted in numerous high-impact publications, reflecting his expertise and contribution to the field. Wang is dedicated to advancing cancer research and improving clinical outcomes through innovative approaches. 🔬📚

Publication Profile

Scopus

Strengths for the Award

1. Innovative Research Focus: Dr. Denian Wang’s research on tumor microenvironment, tumor metabolism, and early diagnosis of lung cancer aligns with cutting-edge areas of cancer research. His work on the immune microenvironment and tumor metabolism is particularly noteworthy for advancing understanding in these critical areas.
2. High-Impact Publications: Dr. Wang has published extensively in high-impact journals such as Nature Communications and Breast Cancer Research. His research is well-regarded in the field, as evidenced by the impact factors of the journals and the citations of his work.
3. Significant Funding: Dr. Wang has secured substantial funding from prominent sources, including the National Natural Science Foundation of China and the Natural Science Foundation of Sichuan Province. This reflects strong support for his research and its perceived importance in the scientific community.
4. Diverse Research Contributions: His diverse publications cover a range of topics within cancer biology and related fields, indicating a broad expertise and a significant contribution to various aspects of the field.

Areas for Improvement

1. Broader Impact and Outreach: While Dr. Wang’s research is highly specialized, increasing efforts to translate findings into clinical practice or public health improvements could enhance the broader impact of his work.
2. Collaborative Networks: Expanding collaborations with international researchers and institutions could further enhance the visibility and impact of his research. This could also facilitate access to additional resources and expertise.
3. Integration of Emerging Technologies: Incorporating emerging technologies, such as advanced bioinformatics or AI-driven approaches, could potentially enhance the scope and impact of his research.

Education

Denian Wang completed his Postdoctoral training in Clinical Medicine at West China Hospital, Sichuan University (2019-2022). He earned his PhD in Cell Biology from the State Key Laboratory of Biotherapy, Sichuan University (2014-2019). His education has provided a robust foundation in clinical and research medicine, equipping him with the skills necessary for cutting-edge research in cancer biology. 🎓🧬

Experience

Denian Wang is currently an Associate Professor at the Precision Medicine Center, West China Hospital, Sichuan University (2022-present). Prior to this, he served as an Associate Professor and Assistant Professor in the Department of Respiratory and Critical Care Medicine at the same hospital (2019-2022). His roles involved advanced research, clinical practice, and mentoring within the fields of respiratory medicine and clinical research. 🏥👨‍⚕️

Research Focus

Denian Wang’s research interests include the tumor microenvironment, tumor metabolism, and immune interactions within cancer. He is particularly focused on early lung cancer diagnosis and using deep learning for malignancy risk estimation. His work aims to enhance understanding of cancer biology and improve diagnostic and therapeutic strategies. 🧪🔍

Publications Top Notes

1. Intermedin protects against sepsis by concurrently re-establishing the endothelial barrier and alleviating inflammatory responses – Nat Commun, 2018. 🌟
2. Sunitinib facilitates metastatic breast cancer spreading by inducing endothelial cell senescence – Breast Cancer Res, 2020. 🌟
3. Blockade of macrophage-associated programmed death 1 inhibits the pyroptosis signalling pathway in sepsis – Inflamm Res, 2021. 🌟
4. Tau aggravates stress-induced anxiety by inhibiting adult ventral hippocampal neurogenesis in mice – Cereb Cortex, 2023. 🌟
5. Endoplasmic Reticulum Peroxynitrite Fluctuations in Hypoxia-Induced Endothelial Injury and Sepsis with a Two-Photon Fluorescence Probe – Anal Chem, 2023. 🌟
6. LACTB suppresses migration and invasion of glioblastoma via downregulating RHOC/Cofilin signaling pathway – Biochem Biophys Res Commun, 2022. 🌟
7. Predictive value of circulating cell-free DNA in the survival of breast cancer patients: A systemic review and meta-analysis – Medicine (Baltimore), 2018. 🌟
8. Simultaneous Monitoring of HOCl and Viscosity with Drug-Induced Pyroptosis in Live Cells and Acute Lung Injury – Anal Chem, 2022. 🌟
9. Intermedin (adrenomedullin 2) promotes breast cancer metastasis via Src/c-Myc-mediated ribosome production and protein translation – Breast Cancer Res Treat, 2022. 🌟
10. 4R Tau Modulates Cocaine-Associated Memory through Adult Dorsal Hippocampal Neurogenesis – J Neurosci, 2021. 🌟

Conclusion:

Dr. Denian Wang is a strong candidate for the Research for Young Scientist Award due to his innovative research, high-impact publications, and significant funding achievements. His work contributes significantly to the understanding of cancer biology and offers potential advancements in early diagnosis and treatment. Addressing areas for improvement, such as broader impact and enhanced collaboration, could further strengthen his position as a leading researcher in his field. Overall, his accomplishments and ongoing contributions make him a deserving candidate for this prestigious award.